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</div> <!--产品展示--> <div class="careazt clearfix zt_indexcompany"> <div class="zt_indexcommenbg zt_company_text"> <p style="text-align:center"> <div style="text-align:right;"> <ol> <li> <span style="line-height:1.5;"><strong><u>吡喹?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>吡喹?/u></strong></span> </li> <li> <br /> </li> <li> <br /> </li> <li> <span style="line-height:1.5;"><strong><u>吡喹?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u> CASQ?5268-74-1</u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u> 英文名:praziquantel</u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u> 分子式:C19H24N2O2 </u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>分子量:312.41</u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u> 含量Q?9%</u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u> 性状Q本品ؓ白色或类白色性粉末,</u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u> 用途:吡喹酮是较理想的新型q谱抗虫和抗血吸虫?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u> </u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>USP30    25公斤U板?  99% </u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u> </u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u> </u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>性状】本品ؓ白色或类白色l晶性粉末;呌。本品在氯仿中易Ӟ在乙醇中溶解Q?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>【药理?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>Q?Q药数学吡喹酮是较理想的新型q谱抗虫和抗血吸虫药,目前q泛用于世界各国吡喹酮能使宿M内血吸虫(包活日本分体血吸虫、曼氏分体血吸虫、埃及分体血吸虫)向肝脏移动,q在肝组l中M。此外,对大多数l虫</u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>成虫及未成熟虫体均有良效。加之,对动物毒性极,是较理想的抗寄生虫药物?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>q有试验证实Q吡喚w能被l虫和吸虫迅速吸Ӟ首先使寄生虫发生瞬间的强直性收~,然后使台胞体外皮q速空泡Ş成,q渐扩大Q最l表皮靡烂,l至溶解。当试管内药物浓度达到治疗血情浓度(U?Q?mg?Qml)?0s卛_生上</u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>q现象,但在体内则需l5min?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>皮层的空泡Ş成,l虫仅发生于虫体前端部位Q而吸虫则发生于全部体表外皮,I形成只发生于合胞体层Q随?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>间g长而扩大病变范围。皮层破坏后Q媄响虫体吸收与排泄功能Q更重要的是其体表抗原暴Ԍ从而易擅受宿主免疫</u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>dQ促使虫体死亡?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>陈上q原发性变化外Q吡喚wq能引vl发性作用,使虫体表膜去极化Q皮层碱性磷酔RzL明N低,以致葡萄p的摄取受阻Q内源性糖原耗竭。此外,吡喹酮尚可抑制虫体的栔R与蛋白质合成?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>(2)药动?多种动物应用吡喹酮的研宄表明Q内服后几乎全部q速由梢化道吸收。血药峰值时_鼠?分钟Q大鼠ؓl5?0分钟Q犬?0?20分钟Qľ约2h。吸收后药物q泛分布于所有组l器官,甚至能透过大鼠血一一脑屏障,且能q入犬的胆什。吡喚w在动物组l器官内的广泛分布,奠定了对寄生于宿d器官?肌肉、脑、腹膜腔、胆和</u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>肠)的虫幼虫和成虫的有效杀灭作用的基础。吡喚w主要在肝脏中q速代谢灭z,如给大鼠?00mgQkg药量Q肝门静脉药物浓度ؓ21Q?mgQmLQ而末梢血Cؓ6Q?mgQmLQ证明了吡喹酮在肝脏中迅速代谢灭zR以同样剂量肌肉或皮下注,血中药物度l待旉更长Q据大鼠、犬、恒河猴的试验表明,?4h内约?0Q?4C―标记的吡喹酮灭zM谢物经屎排泄。对犬的排泄半衰期约3hQ极量犬、小鼠ؓ0Q?Q,l늾?Q?Q原型药物经屎和_便排性?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>【用途?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>(1)?吡喹酮对l늾、山大多数l虫均有高效Ql 0--1 5mgQkg剂量Ҏ展莫Dl虫、贝氏莫Dl虫、球Ҏ</u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>豪虫和无卵黄腺l虫均有i 00%驱杀效吊。对矛T双腔吸虫、胰阔盘吸虫、ľ虫需?0mgQkg量才能有效?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>对细颈囊蚴应以75mgQkgQ连Ns天,杀灭效吊i 00%。吡喚w对ľ、山日本分体吸虫有高效Q?0mgQkg量灭</u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>虫率接近100%?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>(2)牛lO--25mgQkg日量Q连?天,或一ơ内50mgQkgQ对牛细颈囊蚴有高效?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>据国内实늻验证明,吡喹酮对耕牛血吸虫病有高效Q如人工感染蚴的水?25mgQkg)Q黄?30mgQkg)内服</u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>吡喹酮后Q灭虫率分别?9%%?5%~99%。有用第三胃注入15 mgQkg量,直至用药?0天,_便转阴率,均ؓl00Q?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>(3)犬、猫2Q?? mgQkg量内服或皮下注射Q对大豆状带l虫、犬复孔l虫、猫肥颈带i虫、乔伊?Joyeuxi e</u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>lla pasqualei)几乎i00%有效Q对l粒球l虫、多房棘球虫需?--10mgQkg剂量Q始能驱净虫体。对1?4日龄</u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>qD应用更高剂量。对孟氏选宫l虫、宽节裂头虫必L25mgQkg日量Q连?天?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>吡喹酮对犬卫氏肺吸虫亦有良效Q一ơ应?0mgQkg或l OOmgQkgQ有效率分别?7Q?-1 00%?0%--i 00%Q但如按</u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>25mgQkgq用3天,有效率几q? 00%?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>(4)猪吡喚w对猪l颈囊尾蚴有较好效吊Q如以l OmgQkg量,q用l 4天,可杀灭大多数虫体Q若?0mgQkg量,应用</u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u><img src="/Common/KEditer/../../UploadFiles/KEditer/image/20160427/20160427143333_3601.jpg" alt="" />5天,则灭虫率?00Q?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>有h以h工感染血吸虫蚴的猪q行ȝ试验Q按30mgQkg量内服吡喚wQ其灭虫率接q?0%?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>(5)?以l O--20mgQkg量一ơ内服,寚w有轮赖利l虫、漏斗带l虫和节片戴文虫驱虫率接近l 00Q。对鹅、鸭?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>彤剑带虫、斯氏双睄虫、片彤皱q虫、细匙掏虫、微l小体钩l虫和冠状双盔虫亦有高效,l O--20mgQkg</u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>量,药效接近l00Q?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>【注意?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>(1)本品毒性虽极低Q但高剂量偶可动物血情谷而{氨酶d升高现象。治疗血吸虫病时Q个别牛会出C温升</u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>高,肌震颤和瘤胃膨胀{现象?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>(2)大剂量皮下注时Q有时会出现局部刺Ȁ反应。犬、猫出现的全w反?发生率ؓl 0Q?为疼痛、呕吐、下痢?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>x、无力、昏睡等现象Q但多能耐过?/u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>【用法与用量】内服一ơ量每lkg体重牛、羊、猪l O--35mg犬、猫2Q?--5mg</u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u>lO--200mg</u></strong></span> </li> <li> <span style="line-height:1.5;"><strong><u> </u></strong></span> </li> </ol> </div> <ol> <li style="text-align:right;"> <span style="line-height:1.5;"><strong><u></u></strong></span> </li> </ol> </p></div> </div> </div> <!--vip会员--> <div class="careazt clearfix zt_indexcompany"> <img src="/Hall/Vip/images/zt_bottomimg.jpg" alt="" usemap="#bottomMap"/> <map name="bottomMap" id="bottomMap"> <area shape="rect" coords="720,8,927,30" href="http://www.zinrpq.live/SMS/vip.htm" target="_blank" alt=""/> </map> </div> <!--|站底部--> <div class="carea2 clearfix zt_indexcompany zt_index_bottom"> <div 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